Chemo and Elevated Liver Enzymes

Hi Shelly,

I think your oncologist needs a reality check! Looking for other causes for elevated liver enzymes and liver damage when those damages came with the chemotherapy treatment is worth doing, but the most likely cause is the chemo itself as discussed here :

https://pmc.ncbi.nlm.nih.gov/articles/PMC8332851/#:~:text=Hepatotoxicity related to administration of, failure [9-11].

Here is a relevant quote from the link :

' Hepatotoxicity of chemotherapeutic agents such as methotrexate, oxaliplatin, and irinotecan have been well documented and characterized allowing for careful management by oncologists during administration. However, the rapid advance of the field of oncology and introduction of new classes of therapies such as small molecule inhibitors and immunotherapies have introduced new hepatotoxicity challenges and management strategies. This work is a compilation of the hepatotoxicity and recommended management of various chemotherapies and targeted agents, with a focus on the newer classes of targeted anticancer agents.'

On the other hand, five useful supplements for fending off the liver toxic effects of chemotherapy and other toxicities to the heart are 1) Silymarin/Milk Thistle 2) NAC 3) Selenium 4) Zinc 5) Melatonin.

As an example, look at this research on Silymarin/Milk Thistle/Silibinin for chemotherapy related liver toxicity :

https://pubmed.ncbi.nlm.nih.gov/27497728/

Here is a relevant quote from the literature :

' Histopathological studies show ballooning degradation, inflammatory lesions, lipid deposition and hydropic changes in the liver tissue. All the above biochemical and pathological changes induced by AZT+INH treatments were mitigated in rats receiving SBN simultaneously with these hepatotoxins, indicating its hepatoprotective and antioxidant potentials against AZT+INH-induced hepatotoxicity. '

Art