Recovering Kidney Function

Hi Ashlee,

Three very useful supplements for kidney function improvement and protection are:

1. Melatonin

2. NAC

3. Astaxanthin

As regards melatonin, the following link discusses the positive effects that melatonin has on the kidneys :

https://pmc.ncbi.nlm.nih.gov/articles/PMC10047594/#:~:text=Melatonin has been proven to, without regard to the mechanism.

Here is a relevant quote from the link :

' Melatonin has been proven to have beneficial effects in all of these complications. Melatonin also plays a direct renoprotective role. Moreover, it can be helpful in almost every type of kidney injury because inflammation, apoptosis, and oxidative stress occur without regard to the mechanism. Melatonin regulates mitochondrial metabolism and ATP production and protects mitochondria. It inactivates free radicals by attaching one or more electrons and thus reduces oxidative stress. Due to these mechanisms, melatonin enables normal mitochondrial functions and protects patients from subsequent apoptotic implications and the death of kidney cells. '

Regarding NAC and the kidneys, the following link discusses this relationship :

https://www.sciencedirect.com/science/article/pii/S2468024924018503#:~:text=N-acetylcysteine (NAC) has, in preclinical and clinical studies.

Here is a relevant quote from the link :

' N-acetylcysteine (NAC) has shown beneficial effects in both acute kidney disease and chronic kidney disease (CKD) in preclinical and clinical studies. '

On the relationship between astaxanthin and the kidneys, the following link discusses the benefits of astaxanthin for the kidneys :

https://www.frontiersin.org/journals/pharmacology/articles/10.3389/fphar.2023.1142001/full

Here is a relevant quote from the link :

' Accumulated studies have demonstrated that astaxanthin exerts protective effects against oxidative stress-associated mitochondrial dysfunction (Kim and Kim, 2018). Study has shown that the antioxidant ability of astaxanthin is 100 times stronger than GSH, an important mitochondrial anti-oxidative molecule (Chen et al., 2020). Astaxanthin can easily span through the cell membrane, and then exhibits its antioxidant activities by scavenging ROS and enhancing the activities of antioxidant enzymes (Kim and Kim, 2018). Studies have demonstrated that astaxanthin treatment can alleviate mitochondrial dysfunction and rescue kidney function via its antioxidant activities in several kidney diseases, such as DKD (Chen et al., 2020; Naito et al., 2021) and bisphenol A-induced kidney toxicity (Jiang et al., 2020b). '

Using label recommended dosing can be a good starting point.

Art