Safe Pregnancy Liver Supplements?

Hi Millie,

You may be interested in discussing the following supplements with your doctor :

Vitamin D As A Liver Protectant

https://www.sciencedirect.com/science/article/pii/S0168827812003601

A relevant quote from the above link :

' Vitamin D deficiency also closely relates to the severity of non-alcoholic fatty liver disease (NAFLD) and is implicated in the pathogenesis of insulin resistance, a key factor in the development of NAFLD. In preclinical studies, phototherapy and vitamin D supplementation ameliorate NAFLD histopathology, while vitamin D is a powerful anti-fibrotic against thioacetamide liver injury. In liver transplant recipients severe vitamin D deficiency predicts, and vitamin D supplementation prevents, acute cellular rejection. The role of vitamin D in the activation and regulation of both innate and adaptive immune systems may explain its importance in the above liver diseases.

Vitamin D And Pregnancy

https://pubmed.ncbi.nlm.nih.gov/32487800/#:~:text=All pregnant women should be, better maternal and infant outcomes.

A relevant quote from the above link :

'All pregnant women should be supplemented with 600 IU/day of vitamin D3. We discuss evidence indicating that higher vitamin D doses (1000-4000 IU/day) may be convenient to achieve better maternal and infant outcomes. Low maternal vitamin D status during pregnancy may be associated in infants with a higher risk for lower bone mineral content, enamel defects and attention deficit hyperactive disorder.'

Magnesium As A Liver Protectant

https://pmc.ncbi.nlm.nih.gov/articles/PMC6861788/#:~:text=However, we have shown that, blocking the MAPK signaling pathway.

Here is a relevant quote from the link :

' Magnesium deficiency is commonly associated with liver diseases, and may result from low nutrient uptake, greater urinary secretion, low serum albumin concentration, or hormone inactivation. In turn, low magnesium content in serum and liver tissue can lead to the progression of these diseases, due to a disruption in mitochondrial function, defective protein kinase C (PKC) translocation, inflammatory responses, oxidative stress, or metabolic disorders. Furthermore, magnesium supplementation can improve liver function in certain liver diseases.'

Magnesium And Pregnancy

https://pmc.ncbi.nlm.nih.gov/articles/PMC5590399/

Here is a relevant quote from the above link :

' In all pregnancy outcomes, Group C that received effervescent Mg tablet plus multimineral showed a better result than other groups, and frequency of complications of pregnancy was fewer than the other two groups and showed a significant difference. '

Melatonin As A Liver Protectant

https://journals.physiology.org/doi/full/10.1152/ajpgi.00110.2019

Here is a relevant quote from the above link :

' In brief, as described in the following subparagraphs, the positive effects of melatonin have been observed in ischemia-reperfusion injury (IRI), nonalcoholic steatohepatitis (NASH), and alcoholic steatohepatitis, as well as in liver cancer models. The favorable properties of melatonin have been related to 1) inhibition of liver cell death by necrosis or apoptosis (44), 2) direct antioxidant actions (20), and 3) attenuation of mitochondrial damage (33). '

Melatonin And Pregnancy

https://pmc.ncbi.nlm.nih.gov/articles/PMC9775355/#:~:text=It was shown that melatonin, those with early-onset preeclampsia.

Here is a very important quote from the above link that you should definitely read and in fact reading this whole link would be highly worthwhile reading for pregnant or soon to be pregnant women :

' In the last decade, a number of studies have focused on melatonin, discovering the different properties that establish its relevance to human health. From the studies selected in this review, new knowledge on the roles of melatonin emerged: modulator of circadian rhythm, which is important for neurodevelopment in the fetus; anti-inflammatory function against high-risk pregnancy; and stimulation of labor, which is fundamental for the success of vaginal delivery. In addition, the studies confirm its ability to cross the placenta and its role as a component in breastmilk for infants' developing circadian rhythms, as well as after birth, and its ability to reduce oxidative stress in newborns. Although several studies have confirmed that melatonin supplementation in pregnancy and immediately after has a positive effect on the mother and fetus, long-term clinical trials are imperative to reach clinical outcomes that serve as a final consensus about the use of melatonin as a treatment in pregnancy and newborns. This suggests that the use of melatonin in early life could preserve the safety of life in the future. '

Silymarin As A Liver Protectant

https://www.sciencedirect.com/science/article/pii/S277257232200084X

A relevant quote from the above link :

' Available preclinical and clinical evidence indicates that silymarin is a hepatoprotective agent with established antioxidant, anti-inflammatory, antifibrotic effects. An international expert panel of clinicians was convened to discuss combining alcoholic liver disease, nonalcoholic fatty liver disease/metabolic dysfunction-associated fatty liver disease, drug-induced liver injury, and liver cirrhosis under the single definition of TLD, based on the shared pathologic mechanism of oxidative stress. The panel highlighted the significance of silymarin as an antioxidant treatment for TLD.'

Silymarin And Pregnancy From An Animal Study

WARNING

I am only including Silymarin in this list because it is considered one of the best and safer supplements for liver protection in humans, but there is little if any data to support its use during pregnancy, but your doctor may find it as a useful alternative to some drugs used for liver issues during pregnancy which may have the potential for adverse events. In any case your doctor's approval and supervision will be required for all supplements mentioned in this post before using any of them.

https://pubmed.ncbi.nlm.nih.gov/39960637/

A relevant quote from the animal study :

' The results demonstrated that silymarin supplementation significantly reduced the number of stillbirths and the stillbirth rate (P < 0.05). Additionally, silymarin supplementation tended to increase the mean body weight of newborn and healthy piglets (P = 0.10; P = 0.08) and improved the intrauterine growth restriction (IUGR) score (P = 0.07). Silymarin supplementation also significantly increased protein content in sow colostrum (P < 0.05) and showed a trend towards higher total solids and lactose content (P = 0.05; P = 0.09). Furthermore, silymarin supplementation significantly increased immunoglobulin G (IgG), IgA, and IgM levels in sow colostrum (P < 0.05), as well as proline content (P = 0.10). It also significantly increased endothelial nitric oxide synthase (eNOS) levels in umbilical cord blood (P < 0.05). Moreover, silymarin supplementation reduced interleukin-6 (IL-6) levels and increased interleukin-10 (IL-10) levels in umbilical cord blood serum (P < 0.05). In conclusion, silymarin supplementation in late-gestation sow diets has no adverse effects on sow or piglet health. Instead, it promotes placental vascular development, reduces inflammation, and decreases stillbirth and IUGR rates. It also enhances the average birth weight of viable piglets and modulates the composition of sow colostrum, enriching key nutrients, immunoglobulins, and amino acids. '

So these are supplements you can discuss with your doctor to see if she/he will approve and supervise their use if needed and to also make sure that they will be compatible with any medications you are taking or going to be taking.

Best wishes!

Art

Don't do it. No need. Anything can harm a developing fetus. Staying away from electronics and Wi-Fi is the most important thing. Picture scans are not harmless either. Regular ultrasounds should be limited to an absolute minimum. Lots of literature about it. Even FDA warns about it.