Natural Remedies

Seeking Help for Microscopic Colitis After Budesonide Failed

Posted by sonshine6 (Missouri) on 02/12/2024

Found your website and am wondering if Ted or anyone has any thoughts on treating microscopic colitis - specifically, collagenous colitis.

I have tried the mainstream treatment - budesonide - which after taking it 80% of the people relapse - me included. Currently I am trying to manage my symptoms (diarrhea) with diet. I avoid gluten, dairy, sugar (including fruit), grains, legumes, nuts, and nightshades (tomatoes and peppers). But I would prefer to heal the cause (inflammation of the colon caused by collagen buildup in the colon epithelium - which allows water to be retained) rather than just treat the symptoms.

Thank you.

Replied by Art
California
02/12/2024
2091 posts

Hi sonshine6,

The following may be of interest to you :

https://www.nature.com/articles/s41598-022-10400-y

Here is a relevant quote from the link :

' Therefore, our study aimed to investigate the therapeutic efficacy of melatonin in acetic acid (AA)-induced colitis to establish a possible treatment for colitis and its impacts on vital organs. Following colitis induction (2 ml 5% AA, rectally), rats were orally received melatonin (5 mg/kg) once per day for 6 days after colitis induction. Then, histopathological examination of colon, kidney, liver, and spleen was conducted, interleukin-1 beta (IL-1β), tumor necrosis factor-alpha (TNF-α), myeloperoxidase (MPO), malondialdehyde (MDA), glutathione (GSH), and total antioxidant capacity (TAC) levels were assessed in colon tissue. Colitis induction in untreated rats caused necrotic effects in colon tissues, a significant increase in colonic IL-1β, TNF-α, MPO, and MDA levels, and a remarkable decrease in GSH and TAC levels in colon tissue in comparison to the control group. Meanwhile, melatonin treatment reversed these parameters by improving the microscopic and macroscopic colitis features and extra-intestinal (kidney, liver, and spleen) changes in all treated rats compared to the colitis control group. These results denote a reduction in colitis severity due to the anti-inflammatory and anti-oxidative effects of melatonin and its positive impact on the vital organs.

Art